This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 955756.

Network

Beneficiaries

Our 11 Beneficiaries from 8 different countries employed the 15 Early Stage Researchers (PhDs) for 3 years each. They closely collaborated on different research themes, offer joint training activities for the PhDs and researchers outside the Train2Target network, and co-supervise the progress of the doctoral theses.

Partner Organisations

The Partner Organisations (P) offered specialised training for example in form of internships, courses and workshops in their respective field to give all the ESR’s a competitive advantage.

Early Stage Researcher

The Train2Target network trained 15 Early Stage Researchers (ESRs) in all scientific and non-scientific aspects related to the drug discovery process.

ESR 1: Carlos Karan Gurnani Serrano

Host: Università degli Studi di Milano, Department of Pharmacological and Biomolecular Sciences, Italy
Project: Dissecting lipopolysaccharide transport and assembly at the outer membrane.

ESR 2: Tiago Baeta

Host: Centre National de la Recherche Scientifique, Institut de Biologie Structurale, France
Project: Characterisation the LptF/C/A subcomplex and its binding to LPS at atomic scale.

ESR 3: Mitja Maximilian Zdouc

Host: Naicons SrL, Microbiology, Italy
Project: Bio prospecting, compound screening, identification and structural characterization of bioactive molecules.

ESR 4: Raquel Rodriguez Alonso

Host: Université Catholique de Louvain, de Duve Institute, Belgium
Project: Dissecting the interaction between RcsF and the periplasmic domain of IgaA.

ESR 5: Jessica El-Rayes

Host: Université Catholique de Louvain, de Duve Institute, Belgium
Project: Assembly of complexes between lipoproteins and ß-barrel proteins by the BAM machinery.

ESR 6: Laureen Mertens

Host: University of Amsterdam, Swammerdam Insitute for Life Science, The Netherlands
Project: Assembly and dynamics of the LPS transport Lpt machinery and coordination with peptidoglycan (PG) synthetic machineries.

ESR 7: Elisa Consoli

Host: University of Amsterdam, Swammerdam Insitute for Life Science, The Netherlands
Project: Assembly and dynamics of the outer membrane protein inserting BAM machinery and its coordination with peptidoglycan (PG) synthetic machineries

ESR 8: Matthias Winkle

Host: University of Newcastle Upon Tyne, Institute for Cell Molecular Biosciences, United Kingdom
Project: Coordination of peptidoglycan synthesis within outer membrane constriction and LPS synthesis.

ESR 9: Kara Staunton

Host: University of Birmingham, School of Immunity and Infection, United Kingdom
Project: Characterisation of the functional interactions between the subunits of the BAM machinery

ESR 10: Pilar García del Vello Moreno

Host: Università degli Studi di Napoli Federico II, Chemical Sciences, Italy
Project: Characterisation of the LPS and PG and their structural determinants when bound to major proteins involved in its transport across the periplasm.

ESR 11: Elisabete Cardoso Mendes Moura

Host: Università degli Studi di Milano, Department of Pharmacological and Biomolecular Sciences, Italy
Project: Targeting the Lipopolysaccharide transport to develop novel antimicrobial drugs.

ESR 12: Valentina Lucchini

Host: BioVersys AG, Switzerland
Project: Identification of novel cell wall biogenesis inhibitors.

ESR 13: Arancha Lopez Perez

Host: AiCuris GmbH, Germany
Project: Identification and characterization of innovative Penicillin-Binding Protein inhibitors against MDR-Gram negative bacteria.

ESR 14: Federico Corona

Host: University of Newcastle Upon Tyne, Institute for Cell Molecular Biosciences, United Kingdom
Project: Coordination of outer membrane protein assembly with PG synthesis.

ESR 15: Carina Matias

Host: Danish Technical University, Department of Biotechnology and Biomedicine, Denmark
Project: Development of a novel antibiotic treatment.

Supervisors

All of our main and co-supervisors have a wealth of experience in running successful scientific projects resulting in high impact publications, patents and technologies, and in training of numerous PhD and MSc students.

Prof Alessandra Polissi

Università degli Studi di Milano, Department of Pharmacological and Biomolecular Sciences, Italy

Supervisor

Project Coordinator, Main Supervisor ESR 1 and ESR 11, Co-Supervisor ESR 2, ESR 6 and ESR 8

Dr Jean-Pierre Simorre

Centre National de la Recherche Scientifique, Institut de Biologie Structurale, France

Supervisor

Main Supervisor ESR 2, Co-Supervisor ESR 1, ESR 4, ESR 7, ESR 9, ESR 10, ESR 11, ESR 13, and ESR 14

Dr Margherita Sosio

Naicons SrL, Microbiology, Italy

Supervisor

Principal Investigator, Main Supervisor ESR 3

Prof Jean-François Collet

Université Catholique de Louvain, de Duve Institute, Belgium

Supervisor

Main Supervisor ESR 4 and ESR 5, Co-Supervisor ESR 7, ESR 9 and ESR 12

Prof Tanneke den Blaauwen

University of Amsterdam, Swammerdam Insitute for Life Science, The Netherlands

Supervisor

Main Supervisor ESR 6 and ESR 7, Co-Supervisor ESR 3, ESR 4, ESR 8, ESR 10 and ESR 15

Prof Waldemar Vollmer

University of Newcastle Upon Tyne, Institute for Cell Molecular Biosciences, United Kingdom

Supervisor

Main Supervisor ESR 8 and ESR 14, Co-Supervisor ESR 1, ESR 3, ESR 5, ESR 6 and ESR 13

Prof Ian Henderson

University of Birmingham, School of Immunity and Infection, United Kingdom

Supervisor

Main Supervisor ESR 9, Co-Supervisor ESR 5 and ESR 15

Prof Antonio Molinaro

Università degli Studi di Napoli Federico II, Chemical Sciences, Italy

Supervisor

Principal Investigator, Main Supervisor ESR 10, Co-Supervisor ESR 2, ESR11 and ESR 12

Dr Michel Pieren

BioVersys AG, Switzerland

Supervisor

Group Leader Drug Discovery, Main Supervisor ESR 12

Dr Cuong Vuong

AiCuris GmbH, Germany

Supervisor

Principal Scientist, Main Supervisor ESR 13

Prof Morten Sommer

Danish Technical University, Department of Biotechnology and Biomedicine, Denmark

Supervisor

CSO of AntibioTx, Main Supervisor ESR 15